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NEWS Oct 18,2024

Lee Wei Ling, daughter of Singaporean Lee Kuan Yew, dies after suffering from brain disease for many years_1

On October 9, 2023, Lee Wei Ling, the daughter of Singapore’s founding Prime Minister Lee Kuan Yew, passed away at the age of 69. A professional neurologist, Wei Ling had spent years battling brain-related health issues and was involved in a notable dispute with her brother, Prime Minister Lee Hsien Loong, regarding their father’s former residence.

In a heartfelt announcement on Facebook, Lee Hsien Yang, Wei Ling’s brother, confirmed her passing at home. Back in 2020, Wei Ling had opened up about her health struggles, revealing her diagnosis of progressive supranuclear palsy, a neurodegenerative disorder that shares symptoms with Parkinson’s disease.

Reports indicated that Wei Ling described her condition as a debilitating neurological disorder, affecting her movement, eye control, and balance, which often resulted in falls. She also faced challenges with swallowing and reported feelings of choking. In March of this year, Lee Hsien Yang disclosed the seriousness of Wei Ling’s condition.

Wei Ling’s health issues were underscored by a troubling incident she recounted on Facebook, where she got lost during a stroll through Fort Canning Park. This incident led to a fractured bone, requiring a police rescue and hospital care. The context of her professional background as a neurologist made her personal battles all the more poignant.

Since the death of Lee Kuan Yew, the family home has been a contentious issue within Singapore’s first family. In 2017, both Lee Hsien Yang and Lee Wei Ling accused Lee Hsien Loong of neglecting their father’s wishes by seeking to retain the family home for political leverage. Lee Hsien Loong responded through legal channels, refuting their claims and raising questions regarding the last will and testament of their father.

by 529mai.com
NEWS Oct 18,2024

Sino-Singapore Health – Chinese and foreign research teams cooperate to crack the code of intestinal flora structure

On October 8, Shanghai Jiao Tong University announced a significant breakthrough from Professor Zhao Liping’s team at the School of Life Sciences and Technology. In partnership with international researchers, the team published their findings in the prestigious journal *Cell*, revealing two essential microbial groups—termed “keystone functional groups” and “pathogenic functional groups”—that play a vital role in maintaining human health for the first time.

This discovery has the potential to set new standards for assessing gut health and could lead to advancements in personalized microbiome testing technologies, offering powerful solutions for clinical disease prevention and public health management.

According to the researchers, these two microbial groups interact in a “seesaw” model, where fluctuations in their relative abundances directly influence human health. When the keystone functional group is prevalent, the gut microbiota remains healthy. Conversely, an increase in the pathogenic functional group indicates potential health problems. This “seesaw” phenomenon appears across various populations and is crucial for health maintenance.

Recent studies have indicated that gut microbiota supports regular digestive functions and is essential for overall well-being, comparable to a vital organ. However, the scientific community has yet to agree on which specific members constitute the “core microbiota” necessary for good health.

To conduct their study, Zhao Liping’s team examined 110 patients with type 2 diabetes. They developed innovative high-resolution microbiome sequencing and big data analysis methods to classify gut bacteria based on their cooperative or competitive behaviors. They identified 141 bacterial strains that maintained these relationships over time, leading to a network structure resembling a “seesaw,” where the increase of one group leads to the decrease of another, thus impacting human health. Their analysis confirmed that this “seesaw” model is widely evident in gut samples from both patients and healthy individuals, aligning with traits of the “core microbiota.”

The research highlighted that the “seesaw” model comprises beneficial functional groups associated with disease reduction—referred to as “keystone functional groups”—and those linked to disease worsening, known as “pathogenic functional groups.” To emphasize the significance of keystone functional groups, Zhao compared them to “big tree bacteria.” He stressed that a stable gut ecosystem can only flourish like a dense forest when these “big tree bacteria” dominate, effectively limiting the excessive growth of pathogenic strains and harmful bacteria, thereby enhancing overall health.

The team also found that targeted nutritional interventions could alter the balance between these two functional groups, encouraging the dominance of the keystone functional group—”big tree bacteria”—and subsequently improving patient health. “Interestingly, imbalances in their ratios appeared before any disease symptoms, paving the way for personalized prevention, treatment, and health management,” Zhao remarked.

In assessing the study’s impact, Chinese Academy of Sciences academician Zhao Guoping stated, “This research successfully transforms the previously elusive micro-ecosystem into a quantifiable network structure. It signifies a shift from traditional species identification to an ecological analysis of ‘core microbiota function.’ This represents a groundbreaking development in microecological theory and an innovation in microbiome research approaches.”

Looking ahead, Zhao Liping mentioned that recognizing the seesaw dynamics of gut core microbiota—especially the crucial function of “big tree bacteria” in health—opens new avenues for personalized medicine and precision nutrition. “Our goal is to target big tree bacteria and develop a suite of clinically relevant diagnostic and therapeutic solutions, showcasing their effectiveness across various diseases and truly benefiting patients,” he concluded.

by 529mai.com
NEWS Oct 18,2024

Nobel Prize winners in medicine announced, two American scholars won the award

On October 7th, the Nobel Prize in Physiology or Medicine winners were announced, and American researchers Victor Ambros and Gary Ruvkun are among this year’s laureates. They were recognized for their groundbreaking discovery of microRNA and its crucial role in post-transcriptional gene regulation.

The announcement came from the Nobel Committee in Stockholm at approximately 11:30 AM local time, which translates to 5:30 AM Eastern Time.

Last year’s award went to Hungarian-American biotechnologist Katalin Karikó and American scientist Drew Weissman for their vital contributions to the development of messenger RNA (mRNA) vaccines.

As Nobel Week unfolds, the Medical Prize marks the kickoff of several highly esteemed awards across various disciplines, including economics. The winner of the Physics Prize will be unveiled on October 8th at 5:45 AM Eastern Time, followed by the Chemistry Prize, Literature Prize, and Peace Prize recipients announced from October 9th to 11th. The Economics Prize will be revealed on October 14th.

Winning a Nobel Prize comes with a cash award of 11 million Swedish Krona (approximately $1.061 million), which can be shared among up to three recipients. Those honored will be invited to receive their awards during a ceremony on December 10th, the anniversary of Alfred Nobel’s death in 1896, the founder of the prestigious prizes.

by 529mai.com
NEWS Oct 18,2024

Supermoon with partial lunar eclipse charms stargazers across the world – video

On Tuesday night, skywatchers around the world were treated to an incredible spectacle as a supermoon coincided with a partial lunar eclipse. We had the opportunity to speak with an astronomer about this captivating event.

“Lunar eclipses happen when the Earth aligns itself between the sun and the moon,” the astronomer explained. “This positioning causes the Earth’s shadow to cast over the moon, but in this case, it only partially covered the moon, resulting in a partial eclipse.”

When we asked about the significance of such celestial events, the astronomer added, “While a partial lunar eclipse might not be as exhilarating as a total one, it still sparks curiosity and offers a wonderful chance for people to learn more about our universe.”

As this cosmic phenomenon unfolded, many enthusiasts took to social media to share their experiences and photographs. The buzz surrounding the event highlights just how mesmerizing our night sky can be.

by 529mai.com
NEWS Oct 18,2024

Is it interesting that the mayor has lost his prestige and still won’t leave-_1

About two weeks ago, our publication’s “New Yorker Talks” boldly predicted that embattled Mayor Adams was likely entering what we called the “garbage time” of his tenure, just hoping to make it to the finish line without further incident. At the time, this prediction seemed a bit daring, but who could have imagined it would come true so swiftly?

With the recent indictment of Adams himself, the drama has only just reached its first crescendo. Prosecutors have hinted that this is far from the end and that additional charges—or even more defendants—could be forthcoming. Even if no new evidence surfaces, Adams’ decision to deliberately change his phone password to obstruct the investigation could itself warrant charges such as obstructing justice and lying to investigators. On the political front, his core team is rapidly disbanding, creating a chaotic atmosphere. The city council, which has been quietly vying for power against Adams, certainly won’t be showing him any sympathy as he grapples with these challenges.

Looking further ahead, how many influential business and political elites would dare to partner with a scandal-ridden mayor who has become a global media headline? And with such a loss of authority and credibility, how many capable technocrats, who rely on their own merit rather than proximity to power, would still be willing to take direction from him?

The term “garbage time” comes from sports; it describes a game where the outcome is so lopsided that the losing team can no longer change its fate but must simply run out the clock. In this light, Adams’ refusal to resign seems to echo that same scenario—regardless of any grand plans he might have, the reality is that he is utterly outmatched.

Rising from a working-class background, Adams reached the pinnacle of his career through hard work and self-confidence. However, it is this very confidence that now seems to be working against him. His once-assured public statements are increasingly starting to feel more like the antics of a clown. While he brands himself as “the Biden of Brooklyn,” his behavior—marked by near-obsessive arrogance and narcissism—bears a striking resemblance to a “mini Trump.”

by 529mai.com
NEWS Oct 18,2024

Supreme Court Justice, Adumein, Lauds CICFIN on Technological Tools to Address Corruption

Justice Moore Abraham Aseimo Adumein of the Supreme Court recently lauded the Chartered Institute of Forensics and Certified Fraud Investigators of Nigeria (CIFCFIN) for its forward-thinking approach in utilizing technology and forensic tools to combat corruption and financial crimes in Nigeria. He stated, “This is a game changer in winning the war on corruption and financial crimes that are currently draining our nation.”

Justice Adumein made these comments during the 9th Direct Membership Training graduation and Fellowship award ceremony at the EFCC Academy in Abuja, where he also received his own Fellowship from the Institute. He urged Nigerians to unite against corruption, asserting, “Winning the war against corruption is a task for all Nigerians.” He underscored the necessity of personal integrity, saying, “If we examine our consciences and remain firm, honest, just, and equitable in our roles across all areas of endeavor, I believe we can embody the ideals of our renewed National Anthem and create a nation where no one is oppressed—a nation blessed with peace and abundance, leaving behind a legacy of integrity for our children.”

Justice Adumein’s esteemed career within the Nigerian judiciary precedes his rise to the Supreme Court. His commitment to public service earned him the distinction of being one of the few Nigerians selected to pursue a Post Graduate Certificate in Corruption Studies at Hong Kong University, in collaboration with the globally recognized Independent Commission Against Corruption (ICAC) Academy.

Dr. Iliyasu Gashinbaki, President and Chairman-in-Council of CIFCFIN, characterized Justice Adumein as an “anti-corruption warrior,” highlighting the Institute’s honor in partnering with him on their mission to tackle corruption, fraud, and other financial crimes in Nigeria.

In his address titled “Forensics: The Game Changer to Nigeria’s FINTECHs Trillion Naira Loss,” Gashinbaki emphasized the critical importance of forensic investigations in protecting Nigeria’s financial system against fraud and economic crimes. He noted that although Financial Technology (Fintech) companies play a significant role in economic growth within Nigeria and Africa, their rapid expansion also brings heightened risks of fraud, cybercrime, and identity theft.

He encouraged the newly graduated CIFCFIN members to make the most of their training, equipping themselves to tackle Fintech-related fraud and the evolving financial crimes impacting the Nigerian economy. The 9th Direct training cohort comprised 70 newly chartered certified members, with Fellowships awarded to 15 distinguished individuals from various sectors.

by 529mai.com
NEWS Oct 18,2024

I feel I can’t give 100% to anything – including my family – Ask Philippa

In a recent interview, Philippa Perry shared her thoughts on embracing imperfection and the significance of nurturing relationships. “The pressure to be perfect can be incredibly stifling,” she stated, encouraging people to rethink their high standards.

One reader expressed feelings of being unable to fully commit to different aspects of life, such as work, friendships, and family. “I worry that I might lose people or miss opportunities, but somehow, things usually work out,” they confessed. This sentiment revealed they were trapped in a cycle of anxiety over decision-making, often choosing actions out of obligation rather than genuine desire.

Philippa offered a transformative perspective: “Let go of the idea of perfection and aim for 70% instead. Perfectionism can paralyze you and obstruct real connections.” She pointed out the success of the reader’s business, which appears to operate smoothly—a reflection of their abilities despite their internal conflicts.

Drawing from her experience in psychotherapy, Philippa discussed the burden of the “should.” “It seems like you have a massive ‘should’ weighing you down, insisting you must give your all,” she remarked. “Now is the time to question that narrative. Sometimes, this internal pressure can provoke our rebellious side, causing us to disengage completely.”

She emphasized the necessity of listening to one’s emotions instead of adhering to strict expectations. “We all have this inner voice dictating what we ‘should’ do, but there’s also that ‘Underdog’ part of us that just wants to feel good and take action. When you regularly make choices based on obligation, it’s vital to incorporate what you genuinely want.”

Encouraging the reader to adopt an attitude of “that’ll do” instead of striving for perfection, Philippa provided practical suggestions: “Make time for activities that bring you joy. Instead of viewing your daughter as a responsibility, see her as an opportunity to connect. Play, be silly, and create a joyful atmosphere.”

She also highlighted the importance of open dialogue in relationships. “Talk to your wife about your feelings. Acknowledging your struggles can promote understanding and teamwork.” She recommended being intentional about spending quality time with loved ones, even in simple ways, like sharing meals or engaging in fun activities.

In the end, Philippa reminded us of an important truth: “People often regret not spending enough time with their loved ones when reflecting on their lives. Focus on connections over perfection.” Her final message was clear—investing your time and energy into what feels right can lead to a more fulfilling life.

by 529mai.com
NEWS Oct 17,2024

The first saxophone exhibition in China (Guangzhou) -plays- in Guangzhou

The inaugural Guangzhou Saxophone Exhibition wrapped up on October 4th after three impressive days at Zhujiang Piano Dream Park in Guangzhou. This landmark event drew key figures from China’s wind instrument community, including saxophone experts and nearly 600 performers.

The exhibition was designed as a platform for participants to learn from each other and exchange insights on saxophone teaching and performance. It featured over 300 solo artists and more than 30 ensembles from 18 different provinces, municipalities, and autonomous regions across the nation.

Prominent attendees included Yu Hai, Chairman of the Wind Music Society of the Chinese Musicians Association and a renowned conductor; Zhao Ruilin, Vice Chairman of the Wind Music Society and an esteemed educator and performer; Xi Weilang, also a Vice Chairman and distinguished educator; and Yan Qi, Chairman of the Guangdong Wind Music Association, known for his exceptional skill with wind instruments. The event also attracted respected saxophone faculty from several leading music academies who served as judges, instructors, and performers.

The exhibition featured an intense second-round competition alongside an opening concert where judges and expert musicians showcased their talents. Participants took part in specialized lectures, group practice sessions, and a final concert that highlighted the most outstanding performances. The involvement of expert judges and musicians elevated the artistry of the event, captivating the audience with remarkable performances.

A standout feature of the exhibition was the series of lectures by seasoned industry experts, each possessing deep academic backgrounds and extensive hands-on experience, which greatly benefited the performers. The group practice sessions offered contestants a unique opportunity to learn from one another, exchange ideas, and collaboratively enhance their fundamental skills.

The final concert left a lasting impression, showcasing exceptional performances from selected top competitors. Organizers expressed their hope that the exhibition would further drive the development of wind music in Guangzhou and the Greater Bay Area, contributing to the growth of China’s artistic landscape.

Co-hosted by the China Symphony Development Foundation, the Wind Instrument Professional Committee of the China Musical Instrument Association, the Guangzhou Zhujiang Piano Group Co., and Yu Hai’s Studio for Cultural and Artistic Excellence, the event marked a significant milestone in promoting wind instruments in the region.

by 529mai.com
NEWS Oct 17,2024

Flopping at the box office, hated by the critics – could Joker- Folie à Deux possibly be any worse-

Todd Phillips’s supervillain reboot is encountering significant hurdles in its latest installment, with critics highlighting a sluggish narrative and mismatched musical sequences that have even drawn snickers from the film’s own stars.

Just released, “Joker: Folie à Deux” is the sequel to the 2019 sensation “Joker,” which received widespread acclaim and an Oscar for its distinct portrayal of the DC Comics antihero. The film reunites Joaquin Phoenix, who dons the clown makeup once more, alongside Lady Gaga, who not only acts but also sings, marking this entry as a musical.

However, initial reviews have been stark. The Daily Beast labeled it “so bad and so boring it’s absolutely shocking,” while the New York Post described it as “pathologically unnecessary.” Vanity Fair chimed in with remarks calling it “startlingly dull.”

Despite the negative critical response, one might assume audiences are still on board, right? Unfortunately, that’s not the case. Audience scores are currently dishearteningly low at 31%, with many viewers echoing the same concerns regarding the film’s pacing and overall engagement.

Adding to the chatter, particularly among Gaga’s fanbase, there is speculation online that several of her scenes, including some glimpsed in the trailer, have been cut from the final edit. This has ignited a call for the “Gaga cut” to be released.

What do Gaga and Phoenix think about the finished product? An interesting moment during an interview featured the two exchanging nervous smiles when asked about the film. Observers have hinted that Phoenix may have indicated it was “horrible.” Moreover, rumors about potential tensions between Todd Phillips and DC Studios further complicate matters.

Beyond the critiques, the film also grapples with tonal inconsistencies—one minute, the Joker shares dark, suicidal thoughts with Gaga’s character, and the next, they’re performing a lively jazz standard. This jarring contrast hasn’t gone unnoticed by meme creators online.

So how’s it faring at the box office? The film garnered $114.8 million globally during its opening weekend, which may not seem terrible at first glance. However, it’s a stark contrast to the first film’s impressive $248.4 million debut, despite this sequel carrying a budget three times greater. This financial performance could lead it to be branded as a box office flop in addition to its critical setbacks.

The takeaway? It might be wise to suggest a more intimate dinner à deux rather than diving headfirst into the film.

by 529mai.com
NEWS Oct 17,2024

Inheritor of Shiban Music in Southern Fujian- The road is at your feet and the dream is in the distance

In the village of Xiaoxia in Dongshi Town, Jinjiang City, Fujian Province, a traditional folk performance known as Shifan music has flourished for over 200 years, remaining a cherished cultural expression in Jinjiang.

“Shifan music is infused with folk elements, which makes it versatile for various occasions and creates a lively atmosphere,” said Xiao Zhenzuo, a guardian of Minnan Shifan music, in a recent interview. During this year’s Golden Week holiday, he and his students—Cai Yanyu, Cai Weijin, Xu Changqiao, and Xiao Yawen—brought over thirty performers to the “Fujian Citizens’ Grand Stage” to present “Shifan Elegance Celebrating the National Day,” generating an uplifting vibe.

Shifan music employs ten primary instruments, including the pipa, sanxian, erhu, gaohu, dizi, bili, sheng, zhaqin, and banhu, along with a variety of percussion instruments. While its repertoire is rooted in Nanyin (Southern Chinese music), it celebrates the joyful characteristics of folk music.

“The zhaqin is a hallmark instrument of Xiaoxia Shifan. It has ten strings and resembles a small guzheng, but rather than being plucked like a guzheng, it’s played between the palms and upper arms,” explained Cai Yanyu, highlighting how this ancient instrument contributes a soft and enchanting sound to Shifan performances.

When discussing the origins of Xiaoxia Shifan, Xiao Zhenzuo shared an intriguing tale: “During the Qing Dynasty, Xiao Benren and other villagers served in the military and encountered various traditional instruments throughout the country. They longed for home and began to blend these instruments with the local Nanyin style. When they returned, they established the local community group ‘Xiaoxiang Waner Xuan’ to share their newfound skills.”

Preserving folk music isn’t easy, and Shifan music was on the brink of extinction 30 to 40 years ago as younger generations in Xiaoxia prioritized making a living over maintaining the art form. However, Singaporean expatriate Xiao Congming, a passionate admirer of Minnan culture, noticed this decline and returned home to fund instrument purchases and revive “Xiaoxiang Waner Xuan,” thus supporting the continuation of Shifan music.

“Xiao often contributed to the initiative by offering one yuan for each child attending lessons,” Xiao Zhenzuo recalled, smiling at the memory. This amount was significant at the time, attracting many children from the village to learn this art. Xiao Congming frequently attended classes and even joined in on performances with his sheng and xiao.

Coming from a family rich in Shifan tradition, Xiao Zhenzuo began teaching his peers the fundamentals of Shifan music at a young age. At its height, he taught nearly 60 children, many of whom became pivotal members of “Xiaoxiang Waner Xuan.”

Over the years, while many of these students ventured onto different paths, they would return during festivals to perform together, leading to Xiao Zhenzuo’s concerns about the future of Shifan music. Encouraged by local supporters like Xiao Qingqi from the Jinshan Traditional Culture Promotion Association and leaders such as Huang Tianpei from Jinshan Central Primary School, he introduced Shifan music into the school curriculum in 2009.

For the past fifteen years, Xiao Zhenzuo and Cai Yanyu have dedicated themselves to educating successive generations, guiding students from their first exposure to Shifan music to mastering it, even forming ensembles that perform in neighboring cities like Quanzhou and Putian, earning numerous accolades and inspiring other intangible cultural heritage projects to be incorporated into educational institutions.

Xiao Zhenzuo noted that passing on Shifan music faces significant challenges, with a major concern being the lack of qualified instructors. “The unique blend of instruments in Shifan music requires multiple skilled music educators. Right now, it’s just my disciples and a few teachers at the school, which is far from enough. This is a problem nationwide.”

“Nevertheless, I’m optimistic about the future of Shifan music, especially with its introduction in schools,” he asserted. “Over the years, my disciples and I have taught thousands of students the basics of Shifan music, and even if just one percent of them develop a true passion for preserving the tradition, that could mean dozens of future custodians, elevating the art form.”

“The journey has begun, and the dream is within reach,” Xiao Zhenzuo stated as he prepares to establish a Minnan Shifan Training Center. He firmly believes that the commitment he has invested over the years will bear fruit, ensuring that Minnan Shifan music finds a renewed place and direction amidst modernity, thriving for generations to come.

by 529mai.com

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